Proinflammatory cytokine levels in oral lichen planus, oral leukoplakia, and oral submucous fibrosis
Kaur Jasdeep, Jacobs Reinhilde,
소속 상세정보
( Kaur Jasdeep ) - University of Leuven and Oral and Maxillofacial Surgery Department of Imaging and Pathology OMFS-IMPATH Research Group
( Jacobs Reinhilde ) - University of Leuven and Oral and Maxillofacial Surgery Department of Imaging and Pathology OMFS-IMPATH Research Group
KMID : 0355620150410040171
Abstract
Objectives: The objective of this study was to identify salivary and serum concentrations of interleukin (IL)-8, IL-6, and tumor necrosis factor alpha (TNF-α) in patients with oral lichen planus, oral leukoplakia, oral submucous fibrosis, and healthy controls.
Materials and Methods: Patients selected included 54 oral lichen planus (41 to 65 years), 50 oral leukoplakia (42 to 65 years), 51 oral submucous f-brosis (41 to 65 years), and 50 healthy controls (42 to 65 years). Oral lichen planus, oral leukoplakia, and oral submucous fibross cases were diagnosed using histopathological analysis. Salivary and serum cytokine concentrations were measured using enzyme-linked immunoassay kits in all subjects.
Results: The levels of serum and salivary TNF-α, IL-6, and IL-8 were statistically significantlyincreased in oral leukoplakia, submucous fibrosis,and lichen planus in contrast to normal healthy subjects (P<0.05). Serum and salivary correlation analysis revealed strong and highly significant correlations for TNF-α, IL-6, and IL-8 in all groups (r=0.72-0.82, P<0.05).
Conclusion: Salivary and serum cytokines were also elevated when analyzed in oral precancerous lesions. Thus, salivary and serum IL-8, IL-6, and TNF-α levels might act as diagnostic markers for detection of oral precancer.
키워드
Saliva; Oral lichen planus; Oral leukoplakia; Oral submucous fbrosis; Cytokines
원문 및 링크아웃 정보
등재저널 정보